A Palladium-Catalyzed Regioselective Hydroesterification of Alkenylphenols to Lactones with Phenyl Formate as CO Source

An effective Pd­(OAc)2-PPh3 catalyzed hydroesterification of alkenylphenols with phenyl formate as CO surrogate is described. A variety of lactones are obtained in generally high yields with high regioselectivities. In one case, 76% ee is obtained with a chiral ligand.本文报道了一种以甲酸苯酯作为一氧化碳（CO）替代物、经乙酸钯(II)-三苯基膦（Pd(OAc)₂-PPh₃）催化的高效烯基苯酚氢酯化反应。该反应可得到多种内酯产物，通常可获得较高产率与优异的区域选择性；在一例反应中，使用手性配体可得到76%的对映体过量值（ee, enantiomeric excess）。