Protein preference data for male and female mice

These data are from experiments studying protein preference and plasma FGF21 levels in protein-restricted male and female mice conducted at UiT the Arctic University of Norway. These findings will be published Volcko & McCutcheon (2022) bioRxiv. Detailed methods for the experiment can be found in this paper. Full citation to a peer-reviewed publication is expected to follow. Briefly, data are from sessions licking different solutions (casein and/or maltodextrin) in operant chambers, recorded on Med Associates hardware. Accompanying analysis code as a Jupyter notebook is available on Github (https://github.com/mccutcheonlab/ARP). 

The data are provided as a compressed zip file containing the following:

Folder with raw datafiles from sessions with a single bottle of either casein or maltodextrin, and two-bottle choice tests

Excel file with metadata to accompany each raw datafile (ARP3 and ARP5 conditioning and preference metafile.xls)

The raw datafiles are Med Associates files in the stripped format.

ARP3 and ARP5 conditioning and preference metafile.xls contains sheets (metafile_exp1 and metafile_exp2) with the following information for each datafile:

filename

mouse ID

date

diet group (NR, non-restricted or PR, protein-restricted)

sex

cycle stage (for females in the preference test)

nutrient in the left bottle

nutrient in the right bottle

flavor of the solution in the left bottle

flavor of the solution in the right bottle

number of licks to the left bottle

number of licks to the right bottle

phase of the experiment (conditioning sessions or preference test)

ARP3 and ARP5 conditioning and preference metafile.xls also contains sheets (food_intake, BW, female_cycle and FGF21) with data from food intake measurements, body weight measurements, change in food intake and body weight over two cycle in female mice, and plasma FGF21 levels.

本数据集源自挪威北极大学（UiT the Arctic University of Norway）开展的蛋白质偏好与血浆成纤维细胞生长因子21（FGF21）水平研究，实验对象为经蛋白质限制喂养的雌雄小鼠。本研究成果将由Volcko与McCutcheon（2022）发表于预印本平台bioRxiv，实验详细方法可参见该论文，后续将提供经同行评议的正式发表论文的完整引用信息。简而言之，本数据集的数据来自操作性条件反射箱内的舔舐实验：实验动物可接触酪蛋白（casein）和/或麦芽糊精（maltodextrin）溶液，实验数据通过Med Associates硬件设备采集记录。配套的Jupyter Notebook格式分析代码已上传至Github平台（https://github.com/mccutcheonlab/ARP）。

本数据集以zip压缩包形式提供，包含以下内容：
- 收录单瓶酪蛋白舔舐实验、单瓶麦芽糊精舔舐实验及双瓶选择实验原始数据文件的文件夹；
- 配套各原始数据文件的元数据Excel文件（ARP3与ARP5条件化及偏好测试元数据.xls）。

原始数据文件为Med Associates格式的精简版文件。

ARP3与ARP5条件化及偏好测试元数据.xls包含两个工作表（metafile_exp1与metafile_exp2），各工作表记录了每份数据文件的以下信息：
- 文件名
- 小鼠编号
- 实验日期
- 饮食组别（NR：自由进食，或PR：蛋白质限制进食）
- 小鼠性别
- 发情周期阶段（仅针对偏好测试中的雌性小鼠）
- 左侧瓶内营养物质
- 右侧瓶内营养物质
- 左侧瓶内溶液风味
- 右侧瓶内溶液风味
- 左侧瓶舔舐次数
- 右侧瓶舔舐次数
- 实验阶段（条件化训练阶段或偏好测试阶段）

ARP3与ARP5条件化及偏好测试元数据.xls还包含四个工作表（food_intake、BW、female_cycle与FGF21），分别记录了食物摄入量测量数据、体重测量数据、雌性小鼠两个发情周期内食物摄入量与体重变化数据，以及血浆FGF21水平数据。