Data S1 - Alpha-2-Glycoprotein 1(AZGP1) Regulates Biological Behaviors of LoVo Cells by Down-Regulating mTOR Signaling Pathway and Endogenous Fatty Acid Synthesis

Supporting information file containing figures S1–S6. 1. Figure. S1b: The expression of AZPG1 protein in three colorectal cancer cell lines. 2. Figure. S1d: The expression of AZPG1 gene in three colorectal cancer cell lines. 3. Figure. S1f: The relative expression of the AZPG1 gene in blank group, control group and the experimental group. 4. Figure. S3b: The change in FASN, eIF4E,and S6K1 gene after up-regulation of AZGP1 expression in blank group, control group and the experimental group. 5. Figure. S4b: The expression of AZGP1, FASN, eIF4E, p-mTOR, p-S6, and S6K1 after up-regulation of AZGP1 expression in blank group, control group and the experimental group. 6. Figure. S5a: Up-regulation of AZGP1 expression inhibits the proliferation of LoVo cells. 7. Figure. S5e: Up-regulation of AZGP1 expression inhibits the migration of LoVo cells. 8. Figure. S6a: AZGP1 overexpression induces G2 phase arrest in LoVo cells 9. Figure. S6d: AZGP1 overexpression induces a higher rate of apoptosis in LoVo cells.
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本补充信息文件包含图S1至S6。1. 图S1b：三种结直肠癌细胞系中AZPG1蛋白的表达情况。2. 图S1d：三种结直肠癌细胞系中AZPG1基因的表达情况。3. 图S1f：空白组、对照组与实验组中AZPG1基因的相对表达水平。4. 图S3b：在空白组、对照组及实验组中，上调AZGP1表达后FASN、eIF4E与S6K1基因的表达变化。5. 图S4b：在空白组、对照组及实验组中，上调AZGP1表达后AZGP1、FASN、eIF4E、p-mTOR、p-S6及S6K1的表达情况。6. 图S5a：上调AZGP1表达可抑制LoVo细胞的增殖。7. 图S5e：上调AZGP1表达可抑制LoVo细胞的迁移能力。8. 图S6a：AZGP1过表达可诱导LoVo细胞发生G2期阻滞。9. 图S6d：AZGP1过表达可提升LoVo细胞的凋亡率。（XLS格式）