Luecken multiome human bone marrow 2021 s4d8

Dataset published by Luecken et al. 2021 which contains data from human bone marrow measured through joint profiling of single-nucleus RNA and chromatin accessibility using the 10X Genomics Single Cell Multiome ATAC + Gene Expression Kit. All files stored in this entry are from sample 4 donor 8. Additional sample are available upon request. File description filtered_feature_bc_matrix.h5: Filtered feature-barcode matrix containing only detected cell-associated barcodes. raw_feature_bc_matrix.h5: Unfiltered feature-barcode matrix containing every barcode from the list of barcode sequences with at least one read, including background and cell-associated barcodes. s4d8_quality_control.h5ad: Quality controlled cells-feature matrix (filtering low-quality cells, ambient RNA correction, doublet detection). s4d8_normalization.h5ad: Normalized cells-feature matrix (shifted logarithm, scran and pearson residuals normalization). Citation Luecken, M. D. et al. A sandbox for prediction and integration of DNA, RNA, and proteins in single cells. Thirty-fifth Conference on Neural Information Processing Systems Datasets and Benchmarks Track (2021). Original data link https://openproblems.bio/neurips_docs/data/dataset/本数据集由Luecken等学者于2021年发布，包含通过10X Genomics单细胞多组学ATAC+基因表达试剂盒（10X Genomics Single Cell Multiome ATAC + Gene Expression Kit）对人类骨髓进行单核RNA测序与染色质可及性联合谱分析得到的数据。本条目下存储的所有文件均来自供体8的样本4，其余样本可按需申请获取。 filtered_feature_bc_matrix.h5：仅包含已检测到的细胞关联条形码的过滤后特征-条形码矩阵。 raw_feature_bc_matrix.h5：未过滤的特征-条形码矩阵，涵盖所有至少带有一条读段的条形码序列列表中的全部条形码，包括背景条形码与细胞关联条形码。 s4d8_quality_control.h5ad：经过质控处理的细胞-特征矩阵（已完成低质量细胞过滤、环境RNA校正及双细胞检测）。 s4d8_normalization.h5ad：经过标准化处理的细胞-特征矩阵（采用移位对数、scran及皮尔逊残差标准化方法）。 引用信息：Luecken, M. D. 等. 单细胞中DNA、RNA与蛋白质的预测及整合研究沙箱[C]//第三十五届神经信息处理系统大会数据集与基准赛道会议. 2021. 原始数据链接：https://openproblems.bio/neurips_docs/data/dataset/