Pd(II)-Catalyzed Intramolecular 1,2-Aminoalkylation of Conjugated 1,3-Dienes for the Synthesis of Pyrrolizidines

A palladium(II)-catalyzed tandem cyclization reaction involving an intramolecular 1,2-aminoalkylation of N-4,6-dienyl β-keto amides has been developed. This process provides an efficient method for the rapid assembly of pyrrolizidines starting from linear substrates in moderate to good yields and high to excellent diastereoselectivities.本研究开发了一种钯(II)催化的串联环化反应，该反应涉及N-4,6-二烯基β-酮酰胺的分子内1,2-氨基烷基化过程。此方法可从线性底物出发快速构建吡咯里西啶类化合物，产物收率中等至良好，非对映选择性高至优异。