Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

In the context of HIV-vaccine development, this study is a proof-of-concept for a strategy to induce broadly neutralizing antibodies (bnAbs) by selecting for functional improbable mutations in bnAb precursor knock-in mice.

在HIV疫苗研发的背景下，本研究针对一种通过在广谱中和抗体（broadly neutralizing antibodies，bnAbs）前体基因敲入小鼠中筛选功能性稀有突变以诱导广谱中和抗体的策略，开展了概念验证研究。