Structure of K48-linked tri-ubiquitin in complex with cyclic peptide
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Structure of K48-linked tri-ubiquitin in complex with cyclic peptide Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, Non-proteinogenic cyclic peptide (inhibitor), ... Authors: Lubkowski, J, Fushman, D, Lemma, B. Deposit date: 2022-11-05 Release date: 2023-11-01 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation. Nat Commun, 14, 2023
与环肽(cyclic peptide)结合的K48连接型三泛素(K48-linked tri-ubiquitin)的结构
描述:4-(2-羟乙基)-1-哌嗪乙磺酸、甘油、非蛋白源性环肽(抑制剂)等
作者:Lubkowski J、Fushman D、Lemma B
提交日期:2022-11-05
发布日期:2023-11-01
最后修改日期:2026-03-04
实验方法:X射线衍射(X-RAY DIFFRACTION),分辨率1.85埃(Å)
引用文献:《蛋白酶体降解大环肽抑制剂对Lys48连接型多泛素的选择性识别机制》,《自然·通讯》(Nat Commun),2023年,第14卷
创建时间:
2022-11-05



