Comparison of Previously Reported Associations to AIS with Results from the Present Study.

The marker rs11190870 at LBX1 is significantly associated in our European population while rs6570507 at GPR126 is nominally associated in the present study. Our study does not show evidence of association to AIS in CHL1 and SOX9. The marker rs10510181 at CHL1 was originally identified in a European population while markers at GPR126, LBX1 and SOX9 were discovered in Asian populations. rs10510181 and rs11190870 were imputed in this study. Previously Published Data reported from [14, 19, 30].
Comparison of Previously Reported Associations to AIS with Results from the Present Study.

本研究的欧洲人群队列中，LBX1基因区域的rs11190870遗传标记与青少年特发性脊柱侧凸（Adolescent Idiopathic Scoliosis, AIS）呈显著关联；GPR126基因区域的rs6570507遗传标记则仅呈现名义上的关联。本研究未发现CHL1与SOX9基因区域的遗传标记与AIS存在关联的证据。
CHL1基因区域的rs10510181遗传标记最初在欧洲人群中被鉴定，而GPR126、LBX1及SOX9基因区域的遗传标记则是在亚洲人群中被发现的。rs10510181与rs11190870在本研究中完成了基因型填充。既往发表的相关数据来自文献[14, 19, 30]。
既往报道的AIS关联研究与本研究结果的对比分析