Stereoselective Synthesis of P-Chiral Phosphorus Compounds from <i>N-tert</i>-Butoxycarbonyl Amino Acids

Reaction of the N-t-Boc amino acids alanine and valine with PhPCl2 gives the P-chiral trans-1,3,2-oxazaphospholidinones exclusively. Variable-temperature NMR and examination of the glycine derivative shows that the isomers observed are due to t-Boc rotation.N-叔丁氧羰基（N-t-Boc）氨基酸丙氨酸与缬氨酸与苯基二氯化膦（PhPCl2）发生反应，可专一性生成P-手性反式-1,3,2-氧杂磷杂环戊酮类化合物。借助变温核磁共振（Variable-temperature NMR）技术并对该甘氨酸衍生物开展考察，结果显示所观测到的异构体均源于叔丁氧羰基（t-Boc）的旋转。