The differentially long noncoding RNAs and mRNA in the hippocampus of Nrf2-knockout mice

Non-coding long noncoding RNAs (lncRNAs) and mRNA have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice. Arraystar Mouse LncRNA Microarray V3.0 (Rockville, MA, USA) is designed for the global profiling of mouse lncRNAs and protein-coding transcripts, which is updated from the previous Microarray V2.0. About 35,923 lncRNAs and 24,881 coding transcripts can be detected by the third-generation lncRNA microarray. To compare the profile differences in the hippocampus tissues between Nrf2 (+/+) and Nrf2 (-/-) mice.

长链非编码RNA（long noncoding RNAs, lncRNAs）与信使RNA（mRNA）在Nrf2敲除小鼠的海马体中呈现表达失调。Arraystar小鼠长链非编码RNA芯片V3.0（Arraystar Mouse LncRNA Microarray V3.0，美国马萨诸塞州罗克维尔）专为小鼠长链非编码RNA与蛋白编码转录本的全局表达谱分析而设计，其基于前代芯片V2.0进行了升级更新。该第三代长链非编码RNA芯片可检测约35923条长链非编码RNA与24881条蛋白编码转录本。本研究旨在比较Nrf2野生型（Nrf2 +/+）与Nrf2敲除纯合型（Nrf2 -/-）小鼠的海马体组织的表达谱差异。