Aromatic Polyketides from the Mangrove-Derived <i>Streptomyces</i> sp. SCSIO 40069

A chemical investigation of Streptomyces sp. SCSIO 40069 resulted in the isolation of a series of aromatic polyketides with rare skeletons, including five new compounds RM18c–RM18g (1–5) and three known ones (6–8). Their structures and absolute configurations were determined by diverse methods, including HRMS and NMR spectra, chemical reaction, Snatzke’s method, quantum mechanical–nuclear magnetic resonance (QM-NMR), and X-ray crystallographic analysis. Compounds 1, 2, 4b, and 8 displayed moderate or weak antibacterial activities.本研究对链霉菌属菌株SCSIO 40069（Streptomyces sp. SCSIO 40069）开展化学考察，从中分离得到一系列骨架罕见的芳香聚酮类化合物，涵盖5个新化合物RM18c–RM18g（编号1–5）与3个已知化合物（编号6–8）。借助高分辨质谱（HRMS）、核磁共振（NMR）波谱、化学衍生反应、斯纳茨克法（Snatzke’s method）、量子力学-核磁共振（QM-NMR）以及X射线晶体衍射分析等多种手段，明确了上述化合物的结构及其绝对构型。其中，化合物1、2、4b及8展现出中等或偏弱的抗菌活性。