WP536 - Calcium regulation in cardiac cells - Homo sapiens

Calcium is a common signaling molecule. Once it enters the cytoplasm, it exerts allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular matrix to the cytoplasm alters membrane depolarization. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarization of the heart.

Source: [Wikipedia](https://en.wikipedia.org/wiki/Calcium_signaling)

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP536)

钙是一类常见的信号分子。当其进入细胞质后，可对多种酶与蛋白质产生别构调控（allosteric regulation）效应。钙可在离子通道激活引发的钙离子内流后参与信号转导，亦可作为第二信使参与由G蛋白偶联受体（G protein-coupled receptors）等间接信号转导通路介导的信号传递过程。钙离子从细胞外基质向细胞质的转运会改变膜去极化状态，该现象可见于心脏心室收缩的平台期，在此场景中钙可维持心脏的去极化状态。

本描述来源：[维基百科](https://en.wikipedia.org/wiki/Calcium_signaling)

该信号通路相关蛋白质可通过CPTAC检测门户（CPTAC Assay Portal）获取靶向检测服务。