DataSheet1_Modifiable factors for migraine prophylaxis: A mendelian randomization analysis.pdf

Objective: To examine the causal effect of potentially modifiable risk factors contributing to migraine pathogenesis.
Methods: We performed Mendelian randomization analyses and acquired data from United Kingdom Biobank, FinnGen Biobank, and the MRC IEU OpenGWAS data infrastructure. An inverse-variance weighted (IVW) model was used to examine the relationship between 51 potentially modifiable risk factors and migraine in 3215 participants with migraine without aura (MwoA), 3541 participants with migraine with aura (MwA), and 176,107 controls. We adopted a Bonferroni-corrected threshold of p = 9.8 × 10–4 (.05 divided by 51 exposures) as a sign of significant effect, and a p < .05 was considered as the sign of a suggestive association.
Results: More years of schooling significantly correlated with lower odds of MwoA pathogenesis (OR .57 [95%CI .44 to .75], p < .0001). More vitamin B12 intake (OR .49 [95%CI .24 to .99], p = .046) and lower level of stress [OR 8.17 (95%CI 1.5 to 44.36), p = .015] or anxiety disorder (OR 1.92 × 109 [95%CI 8.76 to 4.23*1017], p = .029) were suggestive to be correlated lower odds of MwoA pathogenesis. More coffee intake (OR .39 [95%CI .22 to .7], p = .001), lower level of eicosapentaenoic acid status (OR 2.54 [95%CI 1.03 to 6.26], p = .043), and more light physical activity (OR .09 [95%CI .01 to .94], p = .046) were suggestive to be associated with lower odds of MwA.
Conclusion: The years of schooling, light physical activity, vitamin B12 intake, and coffee intake were the protective factors for migraine; stress, anxiety, and eicosapentaenoic acid status were harmful factors. Interventions could be developed based on modifying these factors for migraine prophylaxis.

### 研究目标
探究可干预的潜在风险因素对偏头痛发病机制的因果效应。

### 研究方法
本研究采用孟德尔随机化分析（Mendelian randomization），数据来源于英国生物样本库（United Kingdom Biobank）、芬兰基因生物样本库（FinnGen Biobank）以及MRC IEU开放基因组学数据基础设施（MRC IEU OpenGWAS data infrastructure）。我们使用逆方差加权（inverse-variance weighted, IVW）模型，分析了51项潜在可干预风险因素与两类偏头痛的关联：共纳入3215名无先兆偏头痛（migraine without aura, MwoA）患者、3541名有先兆偏头痛（migraine with aura, MwA）患者以及176107名对照个体。本研究采用经Bonferroni校正的显著性阈值p=9.8×10^-4（即0.05除以51个暴露因素）作为显著效应的判定标准，将p<0.05视为存在提示性关联的依据。

### 研究结果
受教育年限越长，无先兆偏头痛的发病风险显著降低（比值比（Odds Ratio，OR）=0.57，95%置信区间（Confidence Interval，CI）：0.44~0.75，p<0.0001）。更高的维生素B12摄入量（OR=0.49，95%CI：0.24~0.99，p=0.046）、更低的应激水平（OR=8.17，95%CI：1.5~44.36，p=0.015）或焦虑障碍（OR=1.92×10^9，95%CI：8.76~4.23×10^17，p=0.029），均提示与无先兆偏头痛发病风险降低相关。此外，更高的咖啡摄入量（OR=0.39，95%CI：0.22~0.7，p=0.001）、更低的二十碳五烯酸（eicosapentaenoic acid）水平（OR=2.54，95%CI：1.03~6.26，p=0.043）以及更多的轻度体力活动（OR=0.09，95%CI：0.01~0.94，p=0.046），均提示与有先兆偏头痛发病风险降低相关。

### 研究结论
受教育年限、轻度体力活动、维生素B12摄入量与咖啡摄入量均为偏头痛的保护性因素；应激水平、焦虑障碍及二十碳五烯酸水平则为偏头痛的危险因素。可基于上述可干预因素开发干预手段，用于偏头痛的预防。