Imbalance of type II and IV collagen expression promote post-traumatic articular capsule fibrosis based on real-time transcriptomics analysis

Post-traumatic joint contracture is the irreversible fibrosis and adhesion of surrounding tissues caused by joint trauma, resulting in joint contracture and stiffness. However, its mechanism is still indeterminate. Our previous research also found that the pathological characteristics of post-traumatic joint capsule fibrosis were closely related time-dependent. In this study, real-time transcriptomics was used to explore the gene-level changes and molecular responses of the articular capsule in rats at different time points after trauma.

创伤后关节挛缩（post-traumatic joint contracture）是关节创伤引发周围组织发生不可逆纤维化与粘连，进而导致关节挛缩及僵硬的病症。但其具体发病机制目前仍未明确。我们前期的研究还发现，创伤后关节囊纤维化的病理特征与时间进程密切相关。本研究采用实时转录组学（real-time transcriptomics）技术，探究大鼠关节囊在创伤后不同时间点的基因水平变化与分子应答反应。