Table 5_Association between periodontal disease and atherosclerosis: a bibliometric analysis.xlsx

BackgroundIn recent years, the relationship between periodontal disease (PD) and atherosclerosis (AS) has garnered significant scholarly attention. Chronic inflammation induced by PD may promote the onset and progression of AS through multiple mechanisms. Given the increasing global incidence of both PD and AS, which adversely affects patients’ quality of life and longevity, further investigation into the interplay between PD and AS is of substantial clinical importance. This study aims to conduct a comprehensive analysis of the association between PD and AS using bibliometric methods.
MethodsArticles and reviews on the association between PD and AS were retrieved from the Web of Science Core Collection (WOSCC) on June 1, 2023. Bibliometric and knowledge mapping analyses were conducted using CiteSpace [6.3.R1 (64-bit) Advanced].
ResultsThrough a bibliometric analysis of the literature published between 2000 and 2023 on the PD-AS relationship, we identified 1,572 relevant studies. The results show a steadily increasing number of studies on this topic annually, with a significant upward trend after 2002. Keyword analysis reveals “atherosclerosis,” “periodontal disease,” “cardiovascular disease,” “Porphyromonas gingivalis,” and “periodontal pathogens” as research hotspots. Collaboration network analysis highlights the United States as the primary contributor to research in this field. Co-citation analysis shows that J Periodontol, J Clin Periodontol, and Circulation are the most frequently cited journals, reflecting their support for research in this area. Document co-citation analysis identifies several high-impact studies focusing on how systemic inflammation induced by periodontitis promotes AS. This study uncovers development trends and research hotspots in the PD-AS relationship and emphasizes the role of international collaboration and high-impact journals in advancing this field. These insights provide valuable references and guidance for future research.
ConclusionPD and AS are global epidemics causing significant distress and imposing a substantial burden. Research on the PD-AS relationship is evolving rapidly and continues to be a critical focus. Elucidating the mechanisms linking PD and AS represents an emerging trend, providing valuable references for future studies.

研究背景：近年来，牙周病（periodontal disease, PD）与动脉粥样硬化（atherosclerosis, AS）之间的关联已受到学术界的广泛关注。牙周病诱发的慢性炎症可通过多种机制促进动脉粥样硬化的发生与发展。鉴于全球范围内牙周病与动脉粥样硬化的发病率均呈上升趋势，且二者均会对患者的生活质量与寿命产生不利影响，深入探究二者之间的相互作用具有重要的临床价值。本研究旨在采用文献计量学方法，对牙周病与动脉粥样硬化的关联开展全面分析。

研究方法：本研究于2023年6月1日从Web of Science核心合集（Web of Science Core Collection, WOSCC）中检索有关牙周病与动脉粥样硬化关联的文献与综述。采用CiteSpace [6.3.R1（64位）高级版] 进行文献计量分析与知识图谱分析。

研究结果：通过对2000年至2023年发表的牙周病-动脉粥样硬化关联相关文献进行文献计量分析，本研究共检索到1572篇相关研究。结果显示，该领域的年度研究数量呈稳步增长趋势，2002年后出现显著上升。关键词分析结果表明，动脉粥样硬化、牙周病、心血管疾病、牙龈卟啉单胞菌（Porphyromonas gingivalis）以及牙周病原体为当前的研究热点。合作网络分析显示，美国是该领域研究的主要贡献者。共被引分析结果显示，《牙周病学杂志》（J Periodontol）、《临床牙周病学杂志》（J Clin Periodontol）与《循环》（Circulation）是该领域被引频次最高的期刊，体现了其对该领域研究的支撑作用。文献共被引分析还识别出多项高影响力研究，聚焦于牙周炎诱发的全身性炎症如何促进动脉粥样硬化的发生。本研究揭示了牙周病与动脉粥样硬化关联领域的发展趋势与研究热点，并强调了国际合作与高影响力期刊对推动该领域发展的重要作用。上述研究结果可为未来相关研究提供宝贵的参考与指导。

研究结论：牙周病与动脉粥样硬化均为全球性流行病，给人类健康带来严重困扰并造成沉重负担。牙周病与动脉粥样硬化关联领域的研究正快速发展，仍是当前的核心研究焦点。阐明二者之间的潜在关联机制是该领域的新兴趋势，可为未来相关研究提供重要参考。