RNA-seq analysis comparing Spry1flox/flox mice back epidermis to the back epidermis derived from Spry1 epidermis specific knockout mice. RNA-seq analysis comparing Spry1flox/flox mice back epidermis to the back epidermis derived from Spry1 epidermis specific knockout mice

We found that Spry1 epidermis specific knockout give rise to back epidermis hyperpigmentaiton highly mimicks tanning response in mouse Overall design: Spry1 epidermis specific knockout were induced by tamoxifen treatment. The epidermis were harvested and compared with the Spry1flox/flox mouse back epidermis for RNA-seq analysis

我们发现，Spry1表皮特异性敲除可引发小鼠背部表皮色素沉着过度，该表型高度模拟晒黑反应。整体实验设计：通过他莫昔芬（tamoxifen）处理诱导Spry1表皮特异性敲除模型，收集背部表皮，并与Spry1flox/flox小鼠的背部表皮进行RNA测序（RNA-seq）分析。