RNA-seq to investigate the role of FliA-transcribed protein coding genes in Salmonella Typhimurium

FliA in S. Typhimurium directs transcription of large numbers of unstable, non-coding RNAs from intragenic promoters. Also in this study, we identify two previously unreported FliA-transcribed protein coding genes, including sdiA, which encodes a transcription factor that responds to quorum sensing signals produced by other bacteria.

鼠伤寒沙门氏菌（S. Typhimurium）中的FliA可介导大量不稳定非编码RNA从基因内启动子处进行转录。本研究同时还鉴定出两个此前未被报道的、受FliA转录调控的蛋白质编码基因，其中包括sdiA——该基因编码一种可响应其他细菌产生的群体感应信号的转录因子。