Table 5_Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis.docx

BackgroundAtopic dermatitis (AD) is a common recurrent chronic inflammatory skin disease, and there is increasing evidence of a possible association between AD and autoimmune diseases.
ObjectivesThis study aimed to summarize existing epidemiological studies on the association between AD and autoimmune diseases and to perform a meta-analysis of combinable results.
MethodsWe conducted a thorough search for cohort studies, case-control studies and cross-sectional studies across the PubMed, Cochrane Library, and Embase databases, from their inception to May 24, 2024, using medical subject headings and relevant keywords. All data were meticulously analyzed using Stata statistical software version 17.0. The protocol was registered on PROSPERO (CRD42024547282).
ResultA total of 26 cohort studies, comprising 1,629,723 patients with atopic dermatitis and 15,106,889 control subjects, were included in this meta-analysis. These studies were published between 2014 and 2024 and included 19 cohort studies, 2 case-control studies, and 5 cross-sectional studies. The current study demonstrated a significant association of atopic dermatitis with autoimmune diseases[HR 1.49, 95% CI (1.31-1.70); P<0.001], including celiac disease, systemic lupus erythematosus, Sjogren’s syndrome, ankylosing spondylitis, alopecia areata, rheumatoid arthritis, vitiligo, thyroid dysfunction, ulcerative colitis.
ConclusionThe results of our study indicate a clear association between atopic dermatitis and autoimmune diseases, both in adults and children. Additionally, women were more likely to have autoimmune disease complications than men. However, due to the limited number of participants in our study, further research is needed to thoroughly investigate the relationship.
Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024547282.

背景：特应性皮炎（Atopic Dermatitis, AD）是一种常见的复发性慢性炎症性皮肤病，越来越多的研究证据表明，AD与自身免疫性疾病之间可能存在关联。
研究目的：本研究旨在总结现有关于AD与自身免疫性疾病关联的流行病学研究，并对可合并的研究结果开展荟萃分析。
研究方法：我们系统检索了PubMed、Cochrane Library及Embase数据库自建库至2024年5月24日的相关文献，采用医学主题词与相关关键词组合的检索策略，纳入队列研究、病例对照研究及横断面研究。所有数据均采用Stata 17.0统计软件进行严谨分析。本研究方案已在PROSPERO平台注册（注册号：CRD42024547282）。
研究结果：本荟萃分析共纳入26项队列研究，涉及1629723名特应性皮炎患者与15106889名对照受试者；其中19项为队列研究、2项为病例对照研究、5项为横断面研究，相关研究发表于2014年至2024年期间。本研究结果显示，特应性皮炎与自身免疫性疾病存在显著关联[风险比（Hazard Ratio, HR）1.49，95%置信区间（Confidence Interval, CI）1.31~1.70；P<0.001]，涵盖乳糜泻、系统性红斑狼疮、干燥综合征、强直性脊柱炎、斑秃、类风湿关节炎、白癜风、甲状腺功能异常及溃疡性结肠炎。
研究结论：本研究结果表明，无论成人还是儿童群体，特应性皮炎与自身免疫性疾病均存在明确关联。此外，女性发生自身免疫性疾病并发症的风险高于男性。但由于本研究纳入的受试者样本量存在局限性，仍需开展进一步研究以深入探讨二者的关联。
系统评价注册信息：系统评价注册链接：https://www.crd.york.ac.uk/PROSPERO/，注册号：CRD42024547282。