BCP-ALL cell line NALM6 with additional chromosome 21

A common finding in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells that chromosome 21 is never lost and often BCP-ALL cells have gained an extra chromosome 21. This implies an important role for chromosome 21 in the pathobiology of BCP-ALL. We therefore developed a BCP-ALL cell line (Nalm-6, a DUX4-rearranged cell line) with an addi-tional chromosome 21 by means of microcell-mediated chromosome transfer.

儿童B细胞前体急性淋巴细胞白血病（pediatric B-cell precursor acute lymphoblastic leukemia, BCP-ALL）细胞中存在一项普遍观测结论：21号染色体从未发生缺失，且BCP-ALL细胞常额外获得一条21号染色体。这提示21号染色体在BCP-ALL的病理生物学过程中发挥关键作用。因此，我们通过微细胞介导染色体转移（microcell-mediated chromosome transfer）技术，构建了携带额外21号染色体的BCP-ALL细胞系（Nalm-6，一种DUX4重排细胞系）。