Diabetic foot exacerbates gut mycobiome dysbiosis in adult patients with type 2 diabetes mellitus

In this project, we explore the differential gut mycobiome profiles between patients with T2DM, T2DM-DF and healthy control subjects.We found that the abundance of Ascomycota and Basidiomycota at the phylum level were significantly changed in T2DM and T2DM-DF, and the abundance of Candida, displayed a remarkable changes in T2DM-DF, they may both identified as gut fungal markers. And simultaneously, the ROC also showed a better accuracy of this predicted results.

本研究旨在探究2型糖尿病（Type 2 Diabetes Mellitus, T2DM）、2型糖尿病合并糖尿病足（Type 2 Diabetes Mellitus with Diabetic Foot, T2DM-DF）患者与健康对照受试者之间的肠道真菌组差异谱。研究发现，在门分类水平上，子囊菌门（Ascomycota）与担子菌门（Basidiomycota）的相对丰度在T2DM及T2DM-DF患者中均发生显著改变；假丝酵母菌属（Candida）的丰度在T2DM-DF患者中呈现显著变化，二者均可被鉴定为肠道真菌标志物。同时，受试者工作特征曲线（Receiver Operating Characteristic curve, ROC）分析显示，该预测结果具备更优的诊断准确率。