Publication status and characteristics of included studies.

*For two studies (one international, one domestic), the leading centre was not determined at the time of REC submission and for one international study there was no intention to define a leading centre.针对两项研究（一项国际研究、一项国内研究），在向伦理审查委员会（Research Ethics Committee）提交审核时，其牵头中心尚未确定；其中涉及的国际研究亦未计划界定牵头中心。