ALL studies identified in the literature search.

ObjectiveIt remains unclear whether low-molecular-weight heparin (LMWH) is effective and safe for intracerebral hemorrhage (ICH) patients. This study presents a meta-analysis for elucidating effect of LMWH on preventing venous thromboembolism (VTE) among ICH patients.MethodsArticles were located by systematically searching PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG DATA, VIP, and SinoMed databases. The literature was independently screened by two authors, who also extracted data and conducted a qualitative evaluation. With regard to outcomes, their risk ratios (RRs) and 95% confidence intervals (CIs) were computed, and the findings were combined using the random effects model by using Mantel-Haenszel approach.Results30 studies involving 2904 patients were analyzed and compared to control group. According to our findings, early low-dose LMWH, prophylaxis for VTE, was related to the markedly reduced deep vein thrombosis (DVT) (3.6% vs. 17.5%; RR, 0.25; 95% CI, 0.18–0.35; p-valueConclusionsOur meta-analysis suggested that early low-dose of LMWH are safe and effective in ICH patients. More extensive, multicenter, high-quality randomized clinical trials (RCTs) should be conducted to validate the findings and inform clinical practice.研究目的：目前尚不清楚低分子量肝素（low-molecular-weight heparin, LMWH）对脑出血（intracerebral hemorrhage, ICH）患者是否兼具有效性与安全性。本研究通过开展荟萃分析，旨在阐明低分子量肝素用于预防脑出血患者静脉血栓栓塞症（venous thromboembolism, VTE）的效果。 研究方法：本研究系统检索了PubMed、Embase、Web of Science、Cochrane图书馆、中国知网（China National Knowledge Infrastructure, CNKI）、万方数据、维普以及中国生物医学文献服务系统（SinoMed）数据库以获取相关文献。由两名研究者独立完成文献筛选、数据提取及质性评价。针对结局指标，计算其风险比（risk ratios, RRs）与95%置信区间（confidence intervals, CIs），并采用Mantel-Haenszel法结合随机效应模型合并研究结果。 研究结果：本研究共纳入30项研究，涉及2904例患者并与对照组进行对比。结果显示，采用早期低剂量低分子量肝素进行静脉血栓栓塞症预防，可显著降低深静脉血栓形成（deep vein thrombosis, DVT）的发生风险（3.6% vs. 17.5%; RR=0.25, 95%CI: 0.18–0.35; p值）。 研究结论：本荟萃分析表明，早期低剂量低分子量肝素用于脑出血患者兼具安全性与有效性。未来需开展更大样本量、多中心、高质量的随机对照试验（randomized clinical trials, RCTs）以验证本研究结果，为临床实践提供参考依据。