Source Data Extended Data Figure 5

This file contains the source data for Extended Data Figure 5a-f.<b>a,b, </b>Boxplots (<b>a</b>) and heatmaps (<b>b</b>) showing ChIP-seq signal changes of H3K27me3 and H3K27ac at different types of 4C regions (gained, lost and unchanged 4C loops) in EV and DKO cells. The same 4C regions are connected by gray lines in the boxplot. <b>c,d, </b>Boxplots (<b>c</b>) and heatmaps (<b>d</b>) of ChIP-seq signal changes of H3K27me3 and H3K27ac at different types of 4C regions (gained, lost and unchanged 4C loops) in S1KO and DKO cells. The same 4C regions are connected by gray lines in the boxplot. <b>e,f, </b>Boxplots (<b>e</b>) and heatmaps (<b>f</b>) showing ChIP-seq signal changes of H3K27me3 and H3K27ac at different types of 4C regions (gained, lost and unchanged 4C loops) in EV and S1KO cells. The same 4C regions are connected by gray lines in the boxplot. Box and whisker plot: whiskers were extended to the furthest value that is no more than 1.5 times the inter-quartile range. The boxes represent the 25th percentile, median, and 75th percentile. The boxes represent the 25th percentile, median, and 75th percentile (<b>a,c,e</b>); n = 2 biologically independent replicates (<b>a-f</b>); two-sided Wilcoxon Signed-Rank paired test (<b>a,c,e</b>).

本文件包含扩展数据图5a-f的源数据。<b>a,b</b>：箱线图（a）与热图（b）展示了EV细胞与DKO细胞中，不同类型4C互作区域（获得、丢失及不变的4C环）的H3K27me3和H3K27ac的染色质免疫共沉淀测序（ChIP-seq）信号变化。箱线图中，相同的4C区域以灰色线条相连。<b>c,d</b>：箱线图（c）与热图（d）展示了S1KO细胞与DKO细胞中，不同类型4C互作区域（获得、丢失及不变的4C环）的H3K27me3和H3K27ac的ChIP-seq信号变化。箱线图中，相同的4C区域以灰色线条相连。<b>e,f</b>：箱线图（e）与热图（f）展示了EV细胞与S1KO细胞中，不同类型4C互作区域（获得、丢失及不变的4C环）的H3K27me3和H3K27ac的ChIP-seq信号变化。箱线图中，相同的4C区域以灰色线条相连。箱须图说明：须线延伸至不超过四分位距1.5倍的最远数据点；箱体分别代表第25百分位数、中位数及第75百分位数，该标注对应子图a、c、e；所有子图（a-f）的生物学独立重复样本数n=2；子图a、c、e采用双侧威尔科克森符号秩配对检验。