Transcriptome-wide mRNA alterations in Streptozotocin induced Type I diabetic mouse heart

We sequenced mRNA from Left Ventricles of Streptozotocin induced Type I diabetic mouse hearts or mock treated controls at 4 weeks post-treatment in order to assess alternative splicing changes. Heart mRNA profiles of Control and Diabetic (STZ:T1D) mice were generated by deep sequencing using Illumina HiSeq 1000.为评估可变剪接变化，本研究对链脲佐菌素（Streptozotocin）诱导的1型糖尿病小鼠心脏左心室，以及处理后4周的假处理对照组样本的mRNA进行了测序。对照组与糖尿病（STZ:T1D）小鼠的心脏mRNA表达谱通过Illumina HiSeq 1000平台完成深度测序构建。