G9a-dependent gene expression in mouse AML cells. Mus musculus

The methyltransferase G9a was found to play a role in the disease progression of a murine model of AML. Mouse HSPCs were transformed with HoxA9/Meis1 and treated with G9a/GLP inhibitor UNC0638. Overall design: We used microarrays to detail the global program of gene expression that depends on the methyltransferase activity of G9a in murine AML cells.

研究发现甲基转移酶（methyltransferase）G9a在急性髓系白血病（Acute Myeloid Leukemia，AML）小鼠模型的疾病进展中发挥作用。将小鼠造血干细胞与祖细胞（Hematopoietic Stem and Progenitor Cells，HSPCs）经HoxA9/Meis1转化后，用G9a/GLP抑制剂UNC0638进行处理。整体实验设计：本研究利用基因芯片技术，解析小鼠急性髓系白血病细胞中依赖于G9a甲基转移酶活性的全局基因表达程序。