Supplementary Material for: Short- and Long-Term Self-Reported Audiovestibular Symptoms of SARS-CoV-2 Infection in Hospitalized and Nonhospitalized Patients

<b><i>Background:</i></b> Audiovestibular symptoms during the acute stage have been reported in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), while very few studies investigated the long-term audiovestibular manifestations of SARS-CoV-2. <b><i>Objective:</i></b> The objective of this study was to examine the occurrence of short- and long-term audiovestibular symptoms associated with SARS-CoV-2 infection. <b><i>Method:</i></b> In this cross-sectional study, a questionnaire was distributed to severe hospitalized cases and nonhospitalized patients with mild disease, all with confirmed SARS-CoV-2 test results. Participants were inquired to report audiovestibular symptoms during the acute phase and at 6-month follow-up after contracting SARS-CoV-2. <b><i>Results:</i></b> A total of 301 participants completed the questionnaire. Auditory symptoms were reported by 21.9% and 1.99% of patients during the acute phase and 6 months post SARS-CoV-2 infection, respectively. During the acute phase of SARS-CoV-2 infection, aural fullness represents the most common symptoms (18.94%) followed by tinnitus (9.97%) and hearing loss (6.31%). Vestibular symptoms were reported by 34% during the acute phase; most commonly was dizziness (29.9%) followed by vertigo (24.25%) and unsteadiness (8.31%). Long-term and persistent vestibular problems were reported by 3.99% patients. There were no statistically significant differences in self-reported audiovestibular symptoms between patients with severe SARS-CoV-2 disease compared to those with mild disease. <b><i>Conclusion:</i></b> The current study showed that audiovestibular symptoms are common among SARS-CoV-2 infected patients during the acute phase of the disease. However, these symptoms are mostly temporary and showed complete spontaneous recovery during the first 2 weeks postinfection.

背景：严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染患者的急性期听前庭症状（audiovestibular symptoms）已有相关报道，但目前鲜有研究探讨SARS-CoV-2感染后的长期听前庭临床表现。
目的：本研究旨在探讨与SARS-CoV-2感染相关的短期及长期听前庭症状的发生情况。
方法：本项横断面研究（cross-sectional study）向经SARS-CoV-2检测确诊的重症住院患者及轻症非住院患者发放问卷，要求参与者报告其感染SARS-CoV-2后急性期及6个月随访期内的听前庭症状。
结果：共计301名参与者完成了问卷调研。在感染SARS-CoV-2后的急性期及感染后6个月，分别有21.9%及1.99%的患者报告存在听觉症状。急性期患者中，耳闷堵感（aural fullness）为最常见的听觉症状（占比18.94%），其次为耳鸣（tinnitus，占比9.97%）及听力下降（hearing loss，占比6.31%）。急性期有34%的患者报告存在前庭症状（vestibular symptoms），其中最常见的为头晕（dizziness，占比29.9%），其次为眩晕（vertigo，占比24.25%）及步态不稳（unsteadiness，占比8.31%）。另有3.99%的患者报告存在长期持续性前庭功能异常。重症与轻症SARS-CoV-2感染患者的自我报告听前庭症状无统计学显著差异。
结论：本研究显示，SARS-CoV-2感染患者在疾病急性期常出现听前庭症状，但此类症状多为一过性，且多数可在感染后2周内自行完全缓解。