Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo

Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive...研究背景：磷脂酰肌醇-3,4,5-三磷酸（Phosphatidylinositol-3,4,5-triphosphate，PtdInsP3）信号通路在多种肿瘤中因抑癌基因PTEN的功能缺失而被异常激活，并可导致组成型……