Table1_Effects of physical training combined with transcranial direct current stimulation on maximal strength and lower limb explosive strength in healthy adults.xlsx

ObjectiveThe purpose of this systematic review and meta-analysis was to investigates whether transcranial direct current stimulation applied during physical training increases muscle strength in comparison with sham tDCS combined with physical training.
MethodsRandomized controlled trials of the effects of tDCS combined physical training intervention on muscle strength and cortical excitability were collected by searching Web of Science, Pubmed, EBSCO, CNKI. The retrieval date ends in April 2024. 11 randomized controlled trials are finally included. The total sample size of the study is 338. The experimental group was subjected to tDCS combined with physical training intervention, and the control group was physical training combined with sham tDCS intervention.
ResultsThere is a significant increase in maximal strength (SMD = 0.38; 95% CI: 0.09, 0.67; p = 0.01) and lower limb explosive strength (MD = 2.90; 95% CI: 1.06, 4.74; p = 0.002) when physical training was performed with tDCS, but not following physical training combined with sham tDCS. Subgroup analysis of the subject population showed an increase in muscle strength in those with training experience following tDCS combined with physical training (SMD = 0.39; 95% CI: 0.08, 0.70; p = 0.01), but not for those without training experience (SMD = 0.29; 95% CI: −0.06, 0.63; p = 0.10). Motor evoked potential (MEP) wave amplitude increased significantly following physical training with tDCS (SMD = 0.71; 95% CI: 0.18, 1.24; p = 0.008), but was not different between groups (SMD = 0.16; 95% CI: −0.33, 0.65; p = 0.52).
ConclusionstDCS combined with physical training intervention can improve muscle strength, lower limb explosive strength and cerebral cortex excitability. Compared to tDCS combined with training of small muscle groups, tDCS combined with training of large muscle groups was more effective in improving muscle strength. Muscle strength was more likely to improve after tDCS combined with physical training in people with physical training experience compared with people without physical training experience. The combination of tDCS with physical training intervention and the sham-tDCS with physical training intervention both increased cortical excitability.
Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO, identifier (CRD42024550454).

研究目的 本项系统评价与Meta分析旨在探究：相较于联合伪经颅直流电刺激（sham tDCS）的体能训练，在体能训练期间施加经颅直流电刺激（transcranial direct current stimulation，tDCS）是否能够提升肌肉力量。
研究方法 本研究通过检索Web of Science、PubMed、EBSCO及中国知网（CNKI）数据库，收集关于经颅直流电刺激联合体能训练干预对肌肉力量与皮层兴奋性影响的随机对照试验，检索截止日期为2024年4月。最终纳入11项随机对照试验，总样本量为338例。其中实验组接受经颅直流电刺激联合体能训练干预，对照组接受联合伪经颅直流电刺激的体能训练干预。
研究结果 联合经颅直流电刺激的体能训练可显著提升最大肌力（标准化均数差（Standardized Mean Difference，SMD）=0.38；95%置信区间（95% confidence interval，95%CI）：0.09~0.67；p=0.01）与下肢爆发力（均数差（Mean Difference，MD）=2.90；95%CI：1.06~4.74；p=0.002），而联合伪经颅直流电刺激的体能训练无此类效果。针对受试者群体的亚组分析显示，对于有训练经验的人群，联合经颅直流电刺激的体能训练可提升其肌肉力量（SMD=0.39；95%CI：0.08~0.70；p=0.01），但对无训练经验人群无显著影响（SMD=0.29；95%CI：-0.06~0.63；p=0.10）。联合经颅直流电刺激的体能训练可显著提升运动诱发电位（motor evoked potential，MEP）波幅（SMD=0.71；95%CI：0.18~1.24；p=0.008），但组间无显著差异（SMD=0.16；95%CI：-0.33~0.65；p=0.52）。
研究结论 经颅直流电刺激联合体能训练干预可提升肌肉力量、下肢爆发力与大脑皮层兴奋性。相较于联合小肌群训练的经颅直流电刺激，联合大肌群训练的经颅直流电刺激在改善肌肉力量方面效果更优。相较于无体能训练经验人群，有训练经验人群在接受经颅直流电刺激联合体能训练后，肌肉力量更易获得提升。经颅直流电刺激联合体能训练与伪经颅直流电刺激联合体能训练均可提升皮层兴奋性。
系统评价注册信息 https://www.crd.york.ac.uk/，PROSPERO平台，注册号：CRD42024550454。