Phosphopantetheine adenylyltransferase (CoaD) in complex with 2-benzyl-N-(3-chloro-4-methylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Phosphopantetheine adenylyltransferase (CoaD) in complex with 2-benzyl-N-(3-chloro-4-methylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Descriptor: 2-benzyl-7-[(3-chloro-4-methylphenyl)amino]-5-methyl-3H-[1,2,4]triazolo[1,5-a]pyrimidin-8-ium, DIMETHYL SULFOXIDE, Phosphopantetheine adenylyltransferase, ... Authors: Mamo, M, Appleton, B.A. Deposit date: 2018-02-22 Release date: 2018-04-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity. J. Med. Chem., 61, 2018

与2-苄基-N-(3-氯-4-甲基苯基)-5-甲基-[1,2,4]三唑并[1,5-a]嘧啶-7-胺结合的磷酸泛酰巯基乙胺腺苷转移酶（Phosphopantetheine adenylyltransferase, CoaD）。描述项：2-苄基-7-[(3-氯-4-甲基苯基)氨基]-5-甲基-3H-[1,2,4]三唑并[1,5-a]嘧啶-8-鎓、二甲基亚砜、磷酸泛酰巯基乙胺腺苷转移酶……作者：Mamo, M、Appleton, B.A. 提交日期：2018-02-22 发布日期：2018-04-04 最后修改日期：2024-03-13 实验方法：X射线衍射（分辨率1.79埃） 引用文献：《具有革兰氏阴性菌抗菌活性的磷酸泛酰巯基乙胺腺苷转移酶抑制剂的发现与优化》，《药物化学杂志》，第61卷，2018年。