Relation of estimated glomerular filtration rate to prediction of all-cause mortality and cardiovascular events of the men and women, aged 35-74 years, free of previous cardiovascular diseases.

Estimated glomerular filtration rate (eGFR) by Chronic Kidney Disease Epidemiology Collaboration;Due to the U shape of the association between eGFR and risk of death or CVD, Cox models were performed with the exclusion of persons with eGFR ≥ 109 mL/min/1.73m2;*Hazard ratio with level 1 standard deviation (std) higher: all eGFR standard deviation (SD) 11.2, age 35-59 eGFR SD 9.3, age 60-74 eGFR SD 11.6;All cause mortality models were adjusted for age (except those stratified by age classes), gender, current smoking , fasting glycemia, systolic blood pressure.Incident cardiovascular diseases models were adjusted for age (except those stratified by age classes), gender, current smoking , fasting glycemia, systolic blood pressure and total cholesterol.采用慢性肾脏病流行病学协作组（Chronic Kidney Disease Epidemiology Collaboration）公式计算的估算肾小球滤过率（estimated glomerular filtration rate, eGFR）；鉴于eGFR与死亡或心血管疾病（cardiovascular disease, CVD）风险之间的关联呈U型分布，本研究在构建Cox比例风险模型时排除了eGFR≥109 mL/min/1.73m²的受试者；*1个标准差升高对应的风险比：总体eGFR的标准差为11.2，35~59岁亚组eGFR标准差为9.3，60~74岁亚组eGFR标准差为11.6；全因死亡率模型已针对年龄（按年龄分层的模型除外）、性别、当前吸烟状态、空腹血糖及收缩压进行校正；新发心血管疾病模型则额外校正了总胆固醇，其余校正协变量与全因死亡率模型一致：年龄（按年龄分层的模型除外）、性别、当前吸烟状态、空腹血糖及收缩压。