Responses to noradrenaline (NA) and sodium nitroprusside (SNP) in the absence and presence of the NOS inhibitor L-NAME (100 µM) in aorta and small mesenteric arteries from male homozygous Line 11 hArgII mice and their male WT littermate controls.

EC5O values are expressed as –log M, Emax values as the maximum response to NA in g, Rmax values as % reversal of the level of pre-contraction in response to 10 µM of the SNP. Values are given as mean ± SEM. n = 4−8 per group.*P0.05,**P0.01,***P0.001 vs WT control (Student’s t-test).