16S rRNA Sequecing Healthy and COVID-19 patients

The development of SARS CoV 2 infection and the relative severity COVID 19 symptoms are due to different factors, where the microbiome seems to play a relevant role. In literature the possible relationships between the gut, lung, nasopharyngeal, or oral microbiome and COVID 19 have been investigated.Here, we analyzed the microbiota obtained from the sole nasal swabs of both positive and negative SARS CoV 2 individuals, in order to define possible differences in terms of bacterial composition in this niche of respiratory tract in relationship to patient's symptoms or features.

严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染的发生发展，以及新型冠状病毒肺炎（COVID-19）症状的相对严重程度由多种不同因素决定，其中微生物组（microbiome）似乎发挥了重要作用。现有研究已针对肠道、肺部、鼻咽部或口腔微生物组与COVID-19之间的潜在关联展开了相关探索。本研究对仅取自新冠病毒检测阳性及阴性受试者的鼻拭子样本中的微生物群进行了分析，旨在明确该呼吸道微生态位内的细菌组成是否会因受试者的症状或个体特征存在差异。