Synthesis of Novel Pyrazolyl-1,3,4-Thiadiazole Analogues

In the present study, we have designed a novel series of pyrazolyl-1,3,4-thiadiazole analogues by accommodating 1,3,4-thiadiazole ring at C – 4 of pyrazole ring with and without an amide linkage; 5-methyl-1,3-diphenyl-<i>N</i>-(5-phenyl-1,3,4-thiadiazol-2-yl)-1<i>H</i>-pyrazole-4-carboxamide and 2-(5-methyl-1,3-diphenyl-1<i>H</i>-pyrazol-4-yl)-5-phenyl-1,3,4-thiadiazole respectively. We have designed this class of heterocycles by keeping a wide audience in mind, which augment their scientific knowledge. Newly synthesized compounds were characterized by ¹H NMR, ¹³C NMR, mass, IR spectral studies. Single crystal X-ray analysis of some compounds also gave insight into the structural information.