Detect circulating miRNA Expression change after exposure to hexavalent chromium (an carcinogen) among occuaptional workers. Homo sapiens

We profiled plasma miRNA expression in workers exposed to Cr(VI), and assessed genetic damage on chromosome and DNA to compare the sensitivity between epigenetic changes and genetic damage for biomarkers Overall design: We screened differently expressed plasma miRNAs between high and low Cr(VI) exposed workers using Agilent miRNA microarray. low exposure : 5.49 ng/ml

本研究对六价铬（Cr(VI)）暴露工人的血浆微小RNA（miRNA）表达谱进行了分析，并对染色体与DNA层面的遗传损伤开展评估，以比较表观遗传改变与遗传损伤作为生物标志物的敏感性。
实验设计概述：本研究采用安捷伦微小RNA芯片（Agilent miRNA microarray），对高、低六价铬暴露工人的血浆差异表达微小RNA进行筛选；其中低暴露组的暴露浓度为5.49 ng/ml。