Osteosarcoma of the hard palate in a dog ˗ case report

ABSTRACT The osteosarcoma (OSA) is the most diagnosed primary bone cancer in canine patients. This work reports a case of a canine, six years old, mongrel, female, intact, with an OSA in the hard palate. Physical examination detected a firm mass in the palate. Thoracic radiographs, hematological and biochemical exams, histopathological exams and computed tomography were requested. A chondroblastic OSA was diagnosed and the tumor was characterized by immunohistochemistry. There was never evidence of metastasis in this case. The treatment consisted of the combination of conventional chemotherapy, metronomic chemotherapy, and palliative care, aiming at greater survival and well-being of the patient since surgical excision was not possible due to the location and extension of the tumor. Osteogenic sarcomas of the hard palate are rarely seen and described in the literature. In this article we present a characterization of the osteosarcoma with uncommon localization in the hard palate.

摘要 骨肉瘤（Osteosarcoma, OSA）是犬类患者中确诊率最高的原发性骨恶性肿瘤。本研究报道一例6岁未绝育雌性混血犬的硬腭骨肉瘤病例。体格检查于其腭部触及质地坚硬的肿物，随后为其实施了胸部X光摄影、血液学检验、生化检测、组织病理学检查以及计算机断层扫描（Computed Tomography, CT）。经免疫组化（immunohistochemistry）检测后确诊为软骨母细胞型骨肉瘤，该病例未出现任何转移征象。由于肿瘤的位置与侵袭范围无法进行手术切除，故采用常规化疗、节拍化疗联合姑息治疗的方案，以期提升患犬的生存期与生活质量。硬腭骨肉瘤在临床中较为罕见，相关文献报道极少。本文针对这一发生于罕见部位（硬腭）的骨肉瘤进行了特征描述。