Haplotype analysis of single nucleotide polymorphisms (SNPs) surrounding the SCA10 locus in the Sioux SCA10 patient.

&SNPs used in this study were originally studied in Almeida et al [14]. †Distance of the SNP is relative to the SCA10 expansion and is expressed in base pairs. Locations upstream and downstream of the SCA10 expansion are denoted by negative and positive values, respectively. *, The common disease haplotype of Mexican and Brazilian families in our SCA10 cohort of 31 families [29]. ?The “SCA10 haplotype” originally described in Almeida et al [14]. NR, not reported by Ameida et al [14], although these SNPs are mentioned by this study. $, “C” allele segregates with SCA10 expansion. No additional sequence changes were seen outside of the SNPs reported.

&本研究使用的单核苷酸多态性（Single Nucleotide Polymorphism, SNP）位点最初由Almeida等[14]开展研究。†该SNP的位置以相对于SCA10扩增区域的距离表示，单位为碱基对（base pair, bp）。其中，SCA10扩增区域的上游和下游分别以负值和正值标注。*本研究纳入的31个SCA10家系队列中，墨西哥与巴西家系的常见疾病单倍型[29]。?Almeida等[14]最初报道的"SCA10单倍型"。NR：Almeida等[14]未报道该内容，但本研究提及了上述SNP位点。$"C"等位基因与SCA10扩增片段共分离。在所报道的SNP位点之外未观察到额外的序列改变。