Phase II Study of Oxaliplatin, Irinotecan, and Capecitabine in Advanced Gastric/Gastroesophageal Junction Carcinoma

Drugs used in chemotherapy, such as oxaliplatin, irinotecan, and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving more than one chemotherapy drug may kill more tumor cells. This phase II trial is studying how well giving oxaliplatin together with irinotecan and capecitabine works in treating patients with metastatic or inoperable locally advanced gastric cancer or gastroesophageal junction adenocarcinoma (cancer).

化疗所用药物，如奥沙利铂（oxaliplatin）、伊立替康（irinotecan）与卡培他滨（capecitabine），可通过不同机制抑制肿瘤细胞分裂，进而阻断其增殖或诱导其凋亡。联合应用多种化疗药物可杀灭更多肿瘤细胞。本项II期临床试验旨在评估奥沙利铂联合伊立替康与卡培他滨治疗转移性或不可切除局部进展期胃癌及胃食管结合部腺癌患者的临床疗效。