Identification of heterogeneous senescence-associated transcriptional programs

We set out to characterize the transcriptional heterogeneity of the senescence program using a large number of whole-transcriptome sequencing datasets generated by us or publicly available. We identify a number of senescence transcriptional signatures associated to specific stresses or cell types. We also merge all the studies to identify and validate the genes that are universally differentially regulated during senescence.

本研究旨在利用自主生成及公开可获取的大规模全转录组测序（whole-transcriptome sequencing）数据集，解析衰老程序（senescence program）的转录异质性（transcriptional heterogeneity）。本研究鉴定出多种与特定应激刺激或细胞类型相关的衰老转录特征（senescence transcriptional signatures）。此外，本研究整合所有纳入的研究数据集，鉴定并验证了衰老过程中普遍发生差异调控的基因。