Increased fitness of pancreatic cancer cells Adapted to nutrient deprivation. Increased fitness of pancreatic cancer cells Adapted to nutrient deprivation

Pancreatic cancer cells adapted to low nutrient conditions share common transcriptional programs that correlate with alterations in open chromatin states. Overall design: RNA-seq, ATAC-seq and Whole Exome-seq (WES) analyses of pancreatic ductal adenocarcinoma cells adapted to low glucose and low glutamine conditions.

适应低营养条件的胰腺癌细胞共享一套共同的转录程序，且该程序与开放染色质状态的改变具有相关性。整体实验设计：对适应低糖与低谷氨酰胺条件的胰腺导管腺癌细胞开展RNA测序（RNA-seq）、转座酶可及性测序（ATAC-seq）以及全外显子组测序（WES）分析。