Chai-Shen Powder alleviates Perimenopausal syndrome by regulating histamine and norepinephrine via the Synaptic Vesicle Cycle Pathway mediated by DNM1 with machine-learning power

Menopause syndrome is a common health issue affecting women. This study combined bioinformatics and machine learning with animal experiments to investigate how the traditional Chinese medicine formula “Chai-Shen Powder” (CSP) works. We found that CSP can modulate a key protein in the brain called DNM1, which helps rebalance two important signaling molecules: histamine and norepinephrine. In animal tests, CSP effectively improved menopause-related symptoms such as disrupted estrous cycles, anxiety-like behaviors and hormonal imbalance. These findings provide new scientific insight into how CSP may alleviate menopausal symptoms.绝经综合征是一类影响女性的常见健康问题。本研究结合生物信息学、机器学习与动物实验，探究中药方剂柴参散（Chai-Shen Powder，CSP）的作用机制。本研究发现，柴参散可调控大脑中的关键蛋白发动蛋白1（DNM1），进而帮助重新平衡两种重要的信号分子：组胺与去甲肾上腺素。在动物实验中，柴参散可有效改善绝经相关症状，包括动情周期紊乱、类焦虑行为与激素失衡。本研究结果为柴参散缓解绝经症状的潜在机制提供了全新的科学视角。