Whole blood DNA methylation samples from HIV positive men [2012 study]

Genome wide DNA methylation profiles of whole blood from HIV positive men. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 480,000 CpGs. Dataset included 24 subjects from the USA. This data set was used as validation set for studying the effect of HIV viral load on host DNA methylation levels. Bisulphite converted DNA from the 24 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip. Subjects had different levels of HIV viral load. This dataset reports DNA methylation data set on 24 subjects that were generated in 2012 (while the other data set of 120 subjects reports DNA meth data generated in 2013). Details on what each sample characteristics and their values represent are provided in the 'characteristics_readme.txt' file.

本数据集涵盖HIV阳性男性全血的全基因组DNA甲基化谱。实验采用Illumina Infinium 450k人类DNA甲基化微珠芯片v1.2（Illumina Infinium 450k Human DNA methylation Beadchip v1.2），对约48万个CpG位点的DNA甲基化水平进行检测并获取全基因组甲基化谱。数据集共纳入来自美国的24名受试者，曾被用作验证集以探究HIV病毒载量对宿主DNA甲基化水平的影响。研究人员将24份样本经亚硫酸氢盐转化后的DNA与该芯片进行杂交。所有受试者的HIV病毒载量水平存在差异。本数据集收录的24名受试者的DNA甲基化数据生成于2012年（另有包含120名受试者的DNA甲基化数据集生成于2013年）。各样本的特征信息及对应取值的详细说明详见'characteristics_readme.txt'文件。