Structural Biology at EMBL Grenoble, IBS-CIBB and IAB

This proposal clusters crystallography and bioSAXS projects at the EMBL Grenoble, IBS-CIBB and IAB. It combines groups working on different topics with a major focus on cell signaling proteins, drug discovery, long non-coding RNAs, nucleic acid-protein complexes, and host-pathogen interactions. The proposers have long-standing experience in the use, as well as the development of beam lines for macromolecular crystallography and biological small angle X-ray scattering and have participated in successive BAG applications over the years, mostly at the ESRF but also at other synchrotrons (i.e. Soleil, Petra III, and Diamond). As Stephen Cusack (former head of EMBL Grenoble) will be retiring at the end of 2023 we propose to change the BAG responsible to Andrew McCarthy for this application round.

本提案将欧洲分子生物学实验室格勒诺布尔分部（EMBL Grenoble）、IBS-CIBB及IAB的晶体学及生物小角X射线散射（bioSAXS）项目进行集群整合。该提案整合了多个研究方向各异的科研团队，核心研究重点涵盖细胞信号通路蛋白、药物研发、长链非编码RNA（long non-coding RNAs）、核酸-蛋白复合物以及宿主-病原体互作。提案申请人团队拥有长期的大分子晶体学与生物小角X射线散射光束线的使用及开发经验，多年来先后多次参与光束线分配组（BAG）的申请工作，主要依托欧洲同步辐射装置（ESRF），同时也使用过Soleil、Petra III与Diamond等其他同步辐射光源。鉴于欧洲分子生物学实验室格勒诺布尔分部前负责人Stephen Cusack将于2023年底退休，本次申请轮次中我们提议将负责该项目的光束线分配组（BAG）负责人更换为Andrew McCarthy。