Mutagenesis in POLH KO and wt RPE1 cell line

We generated POLH knockouts in RPE-1 cell line and treated them with UVA, UVC, and KBrO3 to better understand mutagenesis in xeroderma pigmentosum variant (XP-V) patients. The dataset contains filtered VCF files from the experiments (GRCh37 reference genome). FASTQ raw data is available on NCBI under accession number PRJNA940340.本研究在RPE-1细胞系中构建了POLH基因敲除模型，并分别以UVA、UVC及KBrO3进行处理，旨在深入探究着色性干皮病变异型（XP-V）患者中的诱变机制。该数据集包含了经过筛选的VCF文件，基于GRCh37参考基因组。原始的FASTQ数据可在NCBI上通过项目编号PRJNA940340查询获得。