Nucleotide and amino acid changes and in vivo phenotypes of <i>mip1</i> mutants.

aThe position of the nucleotide change in MIP1 coding sequence is given. bPosition of the equivalent amino acid in human pol γ sequence. cThe average of the median values (fold increase: ↑ and fold decrease: ↓) is reported to wild-type values arbitrarily set to 1. On average, the frequencies of ER colonies in the MSH1 MIP1 and msh1-1 MIP1 strains were 3×10−8 and 140×10−8, respectively. dOnly one set of at least 15 independent cytoductant cultures was carried out. eRelative exonuclease to polymerase activity ratios are given based on the data of Figure 6. Wild-type ratio has been normalized to 1.a. MIP1编码序列内的核苷酸突变位点已明确给出。 b. 人类DNA聚合酶γ（pol γ）序列中的等效氨基酸位点。 c. 本研究以任意设定为1的野生型数值为参照，报告了各样本中位数的平均值（倍数升高：↑，倍数降低：↓）。平均而言，MSH1 MIP1与msh1-1 MIP1菌株的ER菌落频率分别为3×10⁻⁸与140×10⁻⁸。 d. 仅开展了1组至少包含15个独立胞质导合体（cytoductant）的培养实验。 e. 基于图6的实验数据，给出了核酸外切酶与聚合酶的活性相对比值。野生型的该比值已被归一化为1。