Data supporting "Temporal trends of SARS-CoV-2 exposure in adolescents: a longitudinal pilot study nested in a Uganda birth cohort"

This dataset comprises individual-level data of a subset of participants from a longitudinal study nested within the Entebbe Mother and Baby Study (EMaBS) birth cohort, based in Entebbe municipality, Uganda. Data were drawn from three studies that these participants took part in, where samples were collected: pre-pandemic samples (2014–2016) collected during a blood pressure study; pandemic-era samples collected during the POPVAC C trial (2020–2021) (ISRCTN32849447), which evaluated the impact of BCG revaccination on vaccine responses; and samples from the CoHost study (2021–2022), a 12-month longitudinal follow-up assessing SARS-CoV-2 infection and exposure from participants in the POPVAC B randomised controlled trial. The study aimed to analyse temporal trends in SARS-CoV-2 seropositivity in Ugandan adolescents using pre-pandemic (2014-2016) and pandemic-era samples (2020-2022). We utilised previously stored demographic and clinical data, along with bio-banked samples from these three studies.

本数据集来源于乌干达恩德培市恩德培母婴研究（Entebbe Mother and Baby Study, EMaBS）出生队列中嵌套的一项纵向研究的部分参与者个体层面数据。数据来自上述参与者参与的三项采样研究：其一为2014-2016年大流行前的血压研究采集的样本；其二为2020-2021年POPVAC C临床试验（ISRCTN32849447）期间采集的大流行时期样本，该试验评估了卡介苗（BCG）复种对疫苗应答的影响；其三为2021-2022年CoHost研究的样本，该研究针对参与POPVAC B随机对照试验（randomised controlled trial, RCT）的参与者开展为期12个月的纵向随访，以评估其新型冠状病毒（SARS-CoV-2）感染与暴露情况。本研究旨在利用2014-2016年大流行前及2020-2022年大流行时期的样本，分析乌干达青少年人群的新型冠状病毒血清阳性率时序变化趋势。本研究同时使用了此前留存的人口统计学与临床数据，以及上述三项研究的生物样本库样本。