A Single-blind, Randomized, Placebo Controlled, Two-period Crossover fMRI Study to Investigate the Effects of the D3 Antagonist GSK598809 on Neural and Behavioural Responses to Food Reward and Reinforcement After a Single Oral Dose of GSK598809 in Overweight and Obese Subjects.

This novel compound is a new experimental treatment that may help people to stop compulsive overeating. Compulsive overeating or binge eating is one of the main reasons why people are overweight or obese. Recent research has shown that some kinds of overeating may be linked to a brain chemical called dopamine. There is some evidence that blocking the action of this chemical in animals can reduce food intake, particularly of foods that are high in fat and sugar. The purpose of this study is to find out if this compound (which blocks the effects of dopamine) has the same effect in overweight or obese people, as it does in animals.

本新型化合物是一款全新的实验性治疗手段，或可帮助人们终止强迫性暴食行为。强迫性暴食（或称暴食行为）是导致人群超重或肥胖的主要诱因之一。近期研究证实，部分类型的暴食行为与大脑内一种名为多巴胺（dopamine）的神经递质存在关联。现有部分证据表明，在动物模型中阻断该神经递质的作用可减少食物摄入量，尤其对高脂高糖食物的摄入抑制效果更为明显。本研究旨在验证这款可阻断多巴胺作用的化合物，在超重或肥胖人群中是否能产生与动物实验中一致的干预效果。