Associations between polygenic risk scores for Alzheimer’s disease (FDR p-value ≤ 0.018), amyotrophic lateral sclerosis (FDR p-value ≤ 0.0024), and frontotemporal dementia (FDR p-value ≤ 0.0041), and cognitive and physical measures controlling for age, sex, assessment centre, genotyping batch and array and 10 genetic principal components for population structure.

Associations between polygenic risk scores for Alzheimer’s disease (FDR p-value ≤ 0.018), amyotrophic lateral sclerosis (FDR p-value ≤ 0.0024), and frontotemporal dementia (FDR p-value ≤ 0.0041), and cognitive and physical measures controlling for age, sex, assessment centre, genotyping batch and array and 10 genetic principal components for population structure.

本数据集涵盖阿尔茨海默病（Alzheimer’s disease，FDR校正p值≤0.018）、肌萎缩侧索硬化症（amyotrophic lateral sclerosis，FDR校正p值≤0.0024）及额颞叶痴呆（frontotemporal dementia，FDR校正p值≤0.0041）的多基因风险评分（polygenic risk scores），与认知测量指标及躯体测量指标之间的关联数据；所有关联分析均控制了年龄、性别、评估中心、基因分型批次与芯片，以及用于校正群体结构（population structure）的10个遗传主成分（genetic principal components）的混杂影响。