Sources of microbial reference materials

Despite the importance of the microbiome in a wide array of human and environmental health settings, challenges remain in taking accurate and precise measurements of microbial communities. Challenges in measuring microbial communities can be partially addressed through the use of "reference materials," which we interpret as any physical material that can be used for quality control, validation, diagnostics, and standardization in metagenomic, microbiome, or multi-omics workflows. As members of the International Microbiome and Multi'Omics Standards Alliance (IMMSA) Reference Materials Working Group, we collated a list of available sources of microbial reference material standards. Each entry in our list includes a description, type of material, availability, storage requirements, biosafety level, species richness, and more. Due to the geographical composition of the working group, the list of materials may be biased towards materials that are available in regions of North America and Western Europe. This list is a living document, and we welcome revisions and contributions from the global microbiome community. Methods See the README for a complete description, including information on references used to compile the spreadsheet.尽管微生物组在众多人类与环境卫生场景中发挥着关键作用，但对微生物群落进行准确且精密的测量仍存在诸多难题。针对微生物群落测量的难题，可通过使用“参考物质”得到部分解决——本文将其定义为可用于宏基因组学、微生物组学或多组学工作流程中的质量控制、验证、诊断与标准化的各类实体材料。作为国际微生物组与多组学标准联盟（International Microbiome and Multi'Omics Standards Alliance, IMMSA）参考材料工作组的成员，我们整理了一份现有的微生物参考物质标准来源清单。清单中的每一条目均包含材料描述、材料类型、可获取性、储存要求、生物安全等级、物种丰富度等信息。鉴于工作组的地域组成情况，本材料清单可能偏向于北美与西欧地区可获取的材料。本清单为动态更新文档，我们欢迎全球微生物组学界提出修订意见与贡献内容。 方法 详见README文件以获取完整说明，包括整理该电子表格所参考的文献信息。