Sex-specific differences in the pulmonary epigenome in neonatal hyperoxic lung injury

Changes in the H3K27Ac mark in male and female mice on PND7 and PND21 exposed to room air or hyperoxia Overall design: Examination of the effect of hyperoxia on the lung epigenome (H3K27Ac mark) and sex-specific differences

暴露于常压空气或高氧环境的雌雄小鼠，在出生后第7天（PND7）与出生后第21天（PND21）的组蛋白H3K27乙酰化修饰（H3K27Ac）水平变化。实验整体设计：探究高氧暴露对肺部表观基因组（H3K27Ac标记）的影响及性别特异性差异。