Additional file 2 of Identifying novel regulatory effects for clinically relevant genes through the study of the Greek population

Additional file 2: Supplementary Table S1. eQTLs in GM adipose tissues. Supplementary Table S3. GenotypexObesity significant (p<0.05) interactions in GM. Supplementary Table S4. GenotypexSex significant (p<0.05) interactions in GM. Supplmentary Table S5. eQTLs in GM tissues, when including obesity status as a covariate. Supplementary Table S6. Missense significant (FDR<5%) ASE SNPs identified in each tissue of GM. Supplementary Table S7. Replication of eQTLs across GM tissues. Supplementary Table S8. Detection of GM eQTLs using a linear mixed model with a Genotype×Tissue interaction term (FDR<0.05). Supplementary Table S9. Thirty-five eGenes identified in one GM tissue only by both p-value enrichment analysis and linear mixed model with a Genotype×Tissue interaction term. Supplementary Table S10. Replication of eQTLs across populations for each tissue. Supplementary Table S11. Thirty-two eGenes identified in both GM tissues, but not in GTEx-am. Supplementary Table S12. GWAS-eQTL colocalizations (RTC≥0.9) in GM for each tissue. Supplementary Table S14. Sharing of eGene-trait pairs in GM and GTEx-am. Supplementary Table S15. Expression levels of eGenes corresponding to GM specific eGene-trait pairs in GM and GTEx-am. Supplementary Table S16. Secondary, and not primary, eQTL colocalizations with GWAS signals in GM.

附加文件2：补充表S1。GM脂肪组织中的表达数量性状位点（expression quantitative trait locus，eQTL）。补充表S3。GM中基因型×肥胖显著（p<0.05）交互作用。补充表S4。GM中基因型×性别显著（p<0.05）交互作用。补充表S5。将肥胖状态作为协变量纳入分析时，GM组织中的eQTL。补充表S6。在GM各组织中鉴定出的错误发现率（false discovery rate，FDR）<5%的错义突变型显著等位基因特异性表达单核苷酸多态性（allele-specific expression SNP，ASE SNP）。补充表S7。GM各组织间eQTL的跨组织验证结果。补充表S8。采用包含基因型×组织交互项的线性混合模型检测GM的eQTL，错误发现率<5%。补充表S9。仅在单个GM组织中，通过p值富集分析与包含基因型×组织交互项的线性混合模型共同鉴定出的35个表达数量性状基因（expression quantitative trait gene，eGene）。补充表S10。各组织eQTL的跨人群验证结果。补充表S11。在两个GM组织中均检测到，但未在GTEx-am中鉴定出的32个eGene。补充表S12。GM各组织中全基因组关联分析（genome-wide association study，GWAS）与eQTL的共定位结果，区域共定位置信度（RTC）≥0.9。补充表S14。GM与GTEx-am中eGene-性状对的共享情况。补充表S15。GM特异性eGene-性状对对应的eGene在GM与GTEx-am中的表达水平。补充表S16。GM中与GWAS信号存在二次而非一次eQTL共定位的分析结果。